Plant Transcription Factor Database
Previous version: v3.0
Ziziphus jujuba
HD-ZIP Family
Species TF ID Description
XP_015879242.1HD-ZIP family protein
XP_015901902.1HD-ZIP family protein
XP_015879435.1HD-ZIP family protein
XP_015896650.1HD-ZIP family protein
XP_015894877.1HD-ZIP family protein
XP_015885283.1HD-ZIP family protein
XP_015885285.1HD-ZIP family protein
XP_015885281.1HD-ZIP family protein
XP_015885284.1HD-ZIP family protein
XP_015873119.1HD-ZIP family protein
XP_015889483.1HD-ZIP family protein
XP_015890394.1HD-ZIP family protein
XP_015879577.1HD-ZIP family protein
XP_015878685.1HD-ZIP family protein
XP_015885101.1HD-ZIP family protein
XP_015888788.1HD-ZIP family protein
XP_015890191.1HD-ZIP family protein
XP_015898907.1HD-ZIP family protein
XP_015895488.1HD-ZIP family protein
XP_015898575.1HD-ZIP family protein
XP_015898574.1HD-ZIP family protein
XP_015896340.1HD-ZIP family protein
XP_015899167.1HD-ZIP family protein
XP_015892240.1HD-ZIP family protein
XP_015867693.1HD-ZIP family protein
XP_015881131.1HD-ZIP family protein
XP_015881130.1HD-ZIP family protein
XP_015884145.1HD-ZIP family protein
XP_015884152.1HD-ZIP family protein
XP_015888672.1HD-ZIP family protein
XP_015871696.1HD-ZIP family protein
XP_015894591.1HD-ZIP family protein
XP_015881991.1HD-ZIP family protein
XP_015882975.1HD-ZIP family protein
XP_015882797.1HD-ZIP family protein
XP_015882858.1HD-ZIP family protein
XP_015882921.1HD-ZIP family protein
XP_015897558.1HD-ZIP family protein
XP_015884897.1HD-ZIP family protein
XP_015879620.1HD-ZIP family protein
XP_015877999.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401